Tacrolimus monohydrate 109581-93-3 Antibiyotike
Kwishura:T / T, L / C.
Inkomoko y'ibicuruzwa:Ubushinwa
Icyambu cyo kohereza:Beijing / Shanghai / Hangzhou
Ubushobozi bwo gukora:1kg / ukwezi
Tegeka (MOQ):1g
Igihe cyo kuyobora:Iminsi y'akazi
Imiterere y'ububiko:Ubitswe ahantu hakonje, humye, ubushyuhe bwicyumba.
Ibikoresho bipakira:vial, icupa
Ingano yububiko:1g / vial, 5 / vial, 10g / vial, 50g / icupa, 500g / icupa
Amakuru yumutekano:UN 2811 6.1 / PG 3
Intangiriro
Tacrolimus, ni imiti ikingira indwara.Nyuma yo guhindurwa ingingo ya allogeneic, ibyago byo kwangwa ingingo biringaniye.Kugabanya ibyago byo kwangwa ingingo, tacrolimus iratangwa.Uyu muti urashobora kandi kugurishwa nkumuti wingenzi mukuvura indwara ziterwa na T-selile nka eczema na psoriasis.Irashobora gukoreshwa mu kuvura syndrome yumaso yumye mu njangwe nimbwa.
Tacrolimus ibuza calcineurine, igira uruhare mu gukora interleukin-2, molekile iteza imbere no gukwirakwiza ingirabuzimafatizo za T, mu rwego rwo guhangana n’umubiri wize (cyangwa uhuza) n’umubiri.
Ibisobanuro (USP43)
| Ingingo | Ibisobanuro |
| Kugaragara | Ifu yera cyangwa hafi yera ifu ya kristaline |
| Kumenyekanisha | IR, HPLC |
| Gukemura | Kubora cyane muri methanol, gushonga kubuntu muri N, N dimethylformamide no muri alcool, muburyo bwo gushonga mumazi. |
| Ibisigisigi byo gutwikwa | ≤0.10% |
| Umwanda kama (inzira-2) | Ascomycin 19-epimer ≤0,10% |
| Ascomycine ≤0.50% | |
| Desmethyl tacrolimus ≤0,10% | |
| Tacrolimus 8-epimer ≤0.15% | |
| Tacrolimus 8-igereranya ≤0.15% | |
| Umwanda utazwi -I ≤0.10% | |
| Umwanda utazwi -II ≤0.10% | |
| Umwanda utazwi -III ≤0.10% | |
| Umwanda wose ≤1.00% | |
| Guhinduranya neza (nkuko biri) (10mg / ml muri N, Ndimethylformamide) | -110.0 ° ~ -115.0 ° |
| Ibirimo amazi (by KF) | ≤4.0% |
| Umuti usigaye (by GC) | Acetone ≤1000ppm (Mu nzu) |
| Di-isopropyl ether ≤100ppm (Mu nzu) | |
| Ethyl ether ≤5000ppm | |
| Acetonitrile ≤410ppm | |
| Toluene ≤890ppm | |
| Hexane ≤290ppm | |
| Ikizamini cya mikorobe (munzu) | Umubare wa mikorobe yose yo mu kirere ≤100cfu / gm |
| Umusemburo wose hamwe nububiko bwuzuye ≤10cfu / gm | |
| Ibinyabuzima byihariye (Pathogens) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) bigomba kubura | |
| Suzuma (na HPLC) (kuri anhydrous na solvent kubuntu) | 98% ~ 102% |
