Amakuru

Peptide y'umuringa nayo yitwaGHK-cuni urwego rugizwe no guhuzatripeptide-1na ion y'umuringa.Ubushakashatsi bwakozwe bwerekana ko umuringa mu mubiri w’inyamaswa ugira uruhare runini muburyo butandukanye, cyane cyane bitewe n’umuringa ku misemburo ya antioxydeant.Hariho imisemburo myinshi yingenzi mumubiri wumuntu nuruhu ikenera ion z'umuringa.Iyi misemburo igira uruhare mu gushiraho ingirabuzimafatizo, kurwanya anti-okiside no guhumeka.Umuringa ugira kandi uruhare rugaragaza ibimenyetso, bishobora kugira ingaruka kumyitwarire no guhinduranya ingirabuzimafatizo.Iyo peptide y'umuringa ishonga mumazi, yerekana ibara ry'ubururu bwa cyami naryo ryitwa Blue Copper peptide mu nganda.

Ubushakashatsi bwerekana ko peptide y'umuringa ifite inyungu nyinshi zo kwita ku ruhu, ifite akamaro gakomeye mu nganda zo kwisiga.

1. Uruhare rwa peptide y'umuringa muguhindura uruhu

Ubushakashatsi bwerekana peptide y'umuringa ihindura metalloproteinase zitandukanye mugihe cyo kongera kubaka uruhu rwimbeba.Igikorwa cya enzyme iteza imbere kwangirika kwa poroteyine zo mu mubiri zidasanzwe, zishobora kuringaniza kwangirika kwa poroteyine zo mu mubiri zidasanzwe (poroteyine ECM) kandi bikarinda kwangirika kwuruhu rwinshi.Peptide y'umuringa yongera proteoglycan yibanze.Imikorere yiyi proteoglycan ni ukurinda ko habaho inkovu no kugabanya urwego rwo guhindura ibintu bikura (TGF beta), byongera inkovu mugutunganya inteko ya kolagen.

2. Gukangura synthesis ya kolagen

Ubushakashatsi bwinshi bwemeje ko tripeptide-1 itera synthesis ya kolagen, glycosaminoglycan ihitamo hamwe na proteine ​​ntoya glycan deproteinisation.Mubyongeyeho, irashobora kandi kugenga synthesis ya metalloproteinase ifitanye isano.Zimwe muri iyo misemburo izihutisha kwangirika kwa poroteyine zidasanzwe za matrix, mugihe izindi zishobora kubuza ibikorwa bya protease.Ibi byerekana ko peptide y'umuringa ishobora kugenga urwego rwa poroteyine mu ruhu.

3. Kurwanya inflammatory na antioxidant

Byagaragaye ko peptide y'umuringa ibuza gucana igabanya urugero rwa cytokine ikongora nka TGF-beta na TNF-a mu cyiciro gikaze.Tripeptide-1 igabanya kandi kwangiza okiside igenga urwego rwicyuma no kuzimya uburozi bwa aside irike ya lipide peroxidation.

4. Guteza imbere gukira ibikomere

Ubushakashatsi bwinshi bw’inyamaswa bwemeje ko peptide yubururu ifite ubushobozi bwo gukira ibikomere.Mu bushakashatsi bw'urukwavu, peptide y'ubururu y'umuringa irashobora kwihutisha gukira ibikomere, igatera angiogenez, kandi ikongera ibirimo imisemburo ya antioxydeant mu maraso.

5. Kugarura imikorere ya selile yangiritse

Fibroblast ningirabuzimafatizo nyamukuru zo gukira ibikomere no kuvugurura ingirangingo.Ntabwo bashushanya gusa ibice bitandukanye bya matrice idasanzwe, ahubwo banatanga umubare munini wibintu bikura.Ubushakashatsi bwakozwe mu 2005 bwerekanye ko tripeptide-1 ishobora kugarura imbaraga za fibroblast.

Peptide y'umuringa ni ubwoko bwa polypeptide ifite kurwanya gusaza no gusana.Ntishobora guteza imbere umusaruro wubwoko bwa I, IV na VII gusa, ahubwo inateza imbere ibikorwa bya kolagen synthesis selile fibroblast, nikintu cyiza cyane cyo kurwanya gusaza.

Mu rwego rwo gusana, peptide y'umuringa irashobora kurinda fibroblast iterwa na UV, igatezimbere ibikorwa byayo, igabanya ururenda rwa MMP-1, igakemura neza ibintu bitera umuriro biterwa na sensibilité, igakomeza imikorere yinzitizi yuruhu yangiritse kubera ibitera hanze, kandi ifite anti nziza ubushobozi bwa allergique no guhumuriza.Peptide y'umuringa ikomatanya kurwanya gusaza no gusana, ni gake cyane mubikoresho byo kurwanya gusaza no gusana.