Amakuru

Alprostadil, nanone yitwa PGE1, ni ubwoko bwibikoresho bya farumasi, bikoreshwa cyane mubuvuzi no mubice bifitanye isano.Iraboneka nkinshinge cyangwa muburyo bwa suppository hamwe na cream yibanze yo kuvura.Nka kimwe mu bintu by'ingenzi bikoreshwa mu gukora ibikomoka kuri prostaglandine E1 (PGE1), alprostadil igira uruhare runini mu kwagura imiyoboro no kunoza amaraso mu bice bimwe na bimwe by’abarwayi bafite imikorere mibi (ED).Ubuvuzi bwa Clinical bwanzuye ko alprostadil yongera imbaraga mu gusohora irekura aside nitide, itera ingirabuzimafatizo zoroheje zigira uruhare mu gikorwa cyo kwubaka.Byongeye kandi, byagaragaye ko byihuta cyane kuruta imiti gakondo yo mu kanwa iyo itanzwe imbere cyangwa imbere.

Kubijyanye nigikorwa cya farumasi, alprostadil ikora nka reseptor ya prostaglandine agonist, kandi reseptor ya prostaglandine iboneka mumubiri wumuntu.Iki gikorwa gitanga ingaruka nka vasodilation, bigatuma amaraso yiyongera;bronchoconstriction kugabanya ibimenyetso bya asima;kugabanya kugabanya apoptose mu ndwara ziterwa na kanseri;kugabanuka k'umuriro, n'ibindi.Imiterere yimikorere myinshi ituma iba ikintu cyiza muri gahunda zitandukanye zo guteza imbere ibiyobyabwenge, kuva kuvura ED kugeza kuvura kanseri nibindi, bitewe nikibazo cyihariye ibicuruzwa byanyuma bigomba gukemura.

Usibye gutegurwa hagamijwe kuvura indwara zitandukanye binyuze munzira z'ubuyobozi nko gutera inshinge cyangwa formositori;ugereranije nibicuruzwa bisa kumasoko, PGE1 nayo igaragaza ingaruka zoroheje, harimo no kubabara umutwe nyuma yo gukoreshwa, kugeza intege nke zose nyuma yamasaha make;nubwo rimwe na rimwe bibaho, mubisanzwe ntibikorwa gake muburyo bwa dosiye yagenwe, duhereye kumabwiriza maremare yo gukoresha yatanzwe na muganga wanditse.Byongeye kandi, ukurikije ibigeragezo bya siyansi biherutse gukorwa ku rwego mpuzamahanga, muri rusange, igihe cyo gutangira ibikorwa kiratandukanye kuva ku minota 15 gusa kugeza ku minota 30, ariko mubisanzwe ibisubizo biterwa cyane na buri murwayi imiterere y'urubanza.

Muri rusange, PGE1 yerekanye ingaruka zidasanzwe zidasanzwe, cyane cyane kubagabo bafite imyitwarire mibi yimibonano mpuzabitsina nibibazo byimiterere yumubiri Ubusanzwe imiti yateganijwe yananiwe kubera kubura imbaraga zifatika kandi ibibazo byingutu bigomba gukemurwa bihagije, nta mpungenge zubuzima bukomeye ingorane, mubyukuri kubigira amahitamo meza kandi meza.