Ibicuruzwa

Glutathione irashobora kugaragara mugabanutse (GSH), okiside (GSSG), cyangwa muburyo bwa disulfide ivanze kandi iraboneka hose muri sisitemu y’ibinyabuzima ikora nka tiol-disulfide redox ya selile.Glutathione, Oxidized (GSSG) ni verisiyo ya oxydeire isanzwe ibaho kandi ikomeye antioxydeant glutathione (GSH).Muri vivo GSSG yagabanutse gusubira muri GSH ikoresheje NADPH iterwa na enzyme glutathione reductase.Ikigereranyo cya GSH na GSSG gikoreshwa kenshi mugupima urwego rwimyitwarire ya okiside mu ngirabuzimafatizo, hamwe na GSSG yibanda cyane kuri stress ya okiside, bityo bikaba bioindicator ikomeye yubuzima bwa selile.GSSG ikora nka hydrogène yakira muguhitamo kwa NADP + na NADPH kandi irashobora kuba umuterankunga wa hafi muri S-glutathionylation post yahinduwe.GSSG, hamwe na glutathione na S-nitrosoglutathione (GSNO), basanze bifitanye isano na glutamate yamenyekanisha reseptor ya NMDA na AMPA (binyuze muri mo-glutamyl moieties), kandi birashobora kuba neuromodulator.GSSG irashobora gukoreshwa nka substrate yo gusubiramo glutathione reductase.