Orlistat 96829-58-2 Inyongera yimirire
Kwishura:T / T, L / C.
Inkomoko y'ibicuruzwa:Ubushinwa
Icyambu cyo kohereza:Beijing / Shanghai / Hangzhou
Ubushobozi bwo gukora:800kg / ukwezi
Tegeka (MOQ):25kg
Igihe cyo kuyobora:Iminsi y'akazi
Imiterere y'ububiko:Ubitswe ahantu hakonje, humye, ubushyuhe bwicyumba.
Ibikoresho bipakira:ingoma
Ingano yububiko:25kg / ingoma
Amakuru yumutekano:Ntabwo ari ibintu biteje akaga
Intangiriro
Orlistat ni ndende-ikora kandi ikomeye yihariye ya gastrointestinal lipase inhibitor.Ni ifu yera cyangwa ifu yera hafi yubushyuhe bwicyumba, idashonga mumazi, igashonga muri chloroform, kandi igashonga byoroshye muri Ethanol.Ikora enzyme mugukora imiyoboro ya covalent hamwe na serine ikora ya lipase gastrica na lipase pancreatic lipase munda no munda mato.
Orlistat ni ubwoko bwa lipase inhibitor imiti igabanya ibiro.Nibikomoka kuri lipstatine, bishobora kugabanya kwinjiza amavuta yibiribwa no kugabanya ibiro.Iki gicuruzwa gifite uburyo bukomeye bwo guhitamo lipase ya gastrica na lipase pancreatic lipase, nta ngaruka igira ku zindi misemburo igogora (amylase, trypsin, chymotrypsin) na fosifolipase, kandi ntabwo igira ingaruka ku iyinjizwa rya karubone, proteyine na fosifolipide.Ikora enzyme cyane cyane ikoresheje covalent guhuza ibisigisigi bya serine ahantu hakorerwa lipase gastrica na lipase pancreatic lipase mumyanya yigifu, ibuza hydrolysis ya triacylglycerol, igabanya gufata monoglyceride na aside irike yubusa, bityo ikagenzura uburemere bwumubiri.Umuti ntabwo winjizwa na gastrointestinal tract, kandi kubuza lipase birashoboka.
Iki gicuruzwa kandi gifite umurimo wo kugenzura lipide yamaraso.Irashobora kugabanya triglyceride na cholesterol ya lipoprotein nkeya muri serumu y’abarwayi bafite umubyibuho ukabije kandi ikongera igipimo cya lipoproteine yuzuye cyane na lipoproteine.
Iyo orlistat ihujwe nimirire ya calorie nkeya, irakwiriye kuvurwa igihe kirekire kubantu bafite umubyibuho ukabije kandi bafite ibiro byinshi, harimo nabafite ibibazo by’umubyibuho ukabije.Ifite igihe kirekire cyo kugenzura ibiro nko kugabanya ibiro, kubungabunga ibiro no kwirinda kugaruka.Ivuriro ryerekana neza ko imikorere yo kugenzura ibiro ari ingirakamaro cyane mugukoresha igihe kirekire mugihe hamwe nifunguro cyangwa nyuma yisaha imwe yo kurya.
Orlistat irashobora kugabanya umuvuduko w’impanuka ziterwa n’umubyibuho ukabije n’izindi ndwara ziterwa n'umubyibuho ukabije, harimo hypercholesterolemia, diyabete yo mu bwoko bwa II, kwihanganira glucose, hyperinsulinemia, hypertension, no kugabanya ibinure biri mu ngingo.
Ibisobanuro (USP42)
| Ingingo | Ibisobanuro |
| Kumenyekanisha | HPLC, IR |
| Guhinduranya neza | -48.0 ° ~ -51.0 ° |
| Ibirimo amazi | ≤0.2% |
| Ibintu bifitanye isano I. | Orlistat ifitanye isano na A ≤0.2% |
| Ibintu bifitanye isano II | Orlistat ifitanye isano B ≤0.05% |
| Ibintu bifitanye isano III
| Formylleucine ≤0.2% |
| Orlistat ifitanye isano C ≤0.05% | |
| Orlistat ifungura impeta epimer ≤0.2% | |
| D-Leucine orlistat ≤0.2% | |
| Umwanda ku giti cye utazwi ≤0.1% | |
| Ibintu bifitanye isano IV | Orlistat ifitanye isano D ≤0.2% |
| Orlistat ifungura impeta hagati ≤0.1% | |
| Ibintu bifitanye isano V. | Orlistat ifitanye isano E ≤0.2% |
| Umwanda wose (I kugeza V) | ≤1.0% |
| Amashanyarazi asigaye | Methanol ≤0.3% |
| EtOAc ≤0.5% | |
| n-Heptane ≤0.5% | |
| Ibisigisigi byo gutwikwa | ≤0.1% |
| Ibyuma biremereye nka Pb | ≤20ppm |
| Suzuma na HPLC | 98.0% ~ 101.5% (kuri anhydrous, idafite umusemburo) |
